Senolytic Supplement Piperlongumin Aging Supplement - Supports Optimal Cell Repair & Rejuvenation Naturally Eliminate Zombie Cells 1 Month Supply

- PIPERLONGUMINE: Piperlongumine (also called Piplartine or Piperlongumin) is an amide alkaloid constituent of the fruit of the long pepper (Piper Longum), that has been rigorously studied with well-documented health benefits. Piperlongumine has been identified as a natural, plant-derived, potent senolytic, able to selectively kill senescent cells, protecting against age-related disorders. Each 1,000mg serving of our Fermented Long Pepper Extract contains 10mg (1%) of Piperlongumine. - POTENT 30:1 EXTRACT: CellFend’s patent pending Fermented Long Pepper Extract utilizes a potent extraction process at a 30:1 extract ratio, meaning that a single, 1,000mg serving of CellFend’s Fermented Long Pepper Extract is equivalent to 30,000mg of standardized long pepper powder. - ULTRA-HIGH PURITY: Our purity levels are greater than 99%, ensuring our commitment to bringing you as high-quality of a product as possible. - THIRD-PARTY LAB TESTING: Each batch of our product undergoes rigorous and detailed third-party lab testing, to make sure our ingredients are consistently of the highest quality and purity (greater than 99%). - CLASSIFICATIONS / CERTIFICATIONS: GMP Quality Assured, part of the ISO-9001 internationally recognized quality management system, Gluten Free, Vegan, GMO Free, and 100% Natural.

Product description

Fermented Long Pepper Extract

High Quality & Purity

Our product is:

Fermented Long Pepper Extract is one of the most powerful Senolytics found in nature due to its Piperlongumine content

Each 1,000 mg serving of our patent pending Fermented Long Pepper Extract contains 10 mg (1%) of Piperlongumine

What are Senolytics?

What is a Long Pepper?

The long pepper has been grown and cultivated in India and Southeast Asia for hundreds of years, with its fruit being harvested for spices and Ayurvedic medicinal purposes. The traditional name of the long pepper is “pippali” and the scientific name is “piper longum”. Only recently has modern science been able to reconfirm these ancient beliefs with supporting research and clinical trials.

What makes the Long Pepper so special?

The long pepper can be pharmacologically classified as an adaptogenic or stress response regulating medicinal herb, with a broad spectrum of therapeutic bioactivity. Piperlongumine, piperine, and other amide alkaloids have been identified as the major and structurally unique bioactive molecules of the plant.

What is Piperlongumine?

Piperlongumine (also called Piplartine or Piperlongumin) is an amide alkaloid constituent of the fruit of the long pepper (Piper Longum), that has been rigorously studied with well-documented health benefits. Piperlongumine has been identified as a natural, plant-derived, potent senolytic, able to selectively kill senescent cells, protecting against age-related disorders. Each 1,000mg serving of our patent pending Fermented Long Pepper Extract contains 10mg (1%) of Piperlongumine.

What are Senescent Cells (What is Cellular Senescence)?

Senescent cells are cells that no longer divide and enter a permanent state of cell-cycle arrest (where they’re no longer part of a healthy cell cycle). Because they don’t die, they’re often nicknamed “zombie cells”. These cells release chemicals which act as poisons, causing damage to nearby healthy cells, facilitating a downward spiral, and triggering aging and age-related aliments. As we grow older, senescent cells accumulate in our bodies. This process is also known as Cellular Senescence.

1) Accumulation

As we get older, our cells are exposed to more stress, and we start accumulating damaged cells.

2) Damage Surrounding Cells

Sometimes, these damaged cells stop dividing and turn into senescent (zombie) cells - they refuse to die, but stick around and release toxic chemicals that damage surrounding cells. This can become a downward cycle and lead to disease.

3) Immune Response

In some instances, our immune systems can destroy senescent cells. However, as we age, more and more senescent cells build up and are not naturally killed by our immune systems. These senescent cells can then cause serious damage to other cells and lead to disease.

4) Senolytic Agents

Senolytic Agents are certain types of compounds (such as the Piperlongumine in our patent pending Fermented Long Pepper Extract) that target specific senescent cells and destroy them, allowing our cells to revert back to their natural, healthy conditions.

The word “senolytic” comes from a combination of “senescence” and “lytic”, the Greek word for destroying. Senolytics are certain small molecules that can selectively kill senescent (zombie) cells, thereby promoting healthy aging.

Senolytics can act synergistically when taken together. For instance, combining our patent pending Fermented Long Pepper Extract with either quercetin, fisetin, curcumin, tea theaflavins, apigenin, dasatinib, or navitoclax may be more beneficial than just taking them alone. A combination of senolytics can be used to expand the range of senescent cell types that are targeted, maximizing the benefits.

“The Clinical Potential of Senolytics”, Journal of the American Geriatrics Society, 2017 October; 65(10): 2297?2301

Prior to our 30:1 ratio extraction process, our long pepper undergoes a 96-hour fermentation, which has multiple benefits.

Research shows that fermentation increases the amount of beneficial micro-organisms and bioactive substances, such as phenolic compounds, amino acids, and antioxidants.

Further, fermentation can also improve the bioavailability of the supplement and the body’s ability to better absorb it.

(“Recent research process of fermented plant extract: a review”, Trends in Food Science & Technology 65, 2017, 40-48)